The thing I always guard against when I'm talking to people I'm working with about a script is that there's a thing I don't like and it's called "talk story." It's when you're talking about the story; the characters are tasked with talking about the story instead of allowing the audience to experience the story.

Because the character is a fiction, he's a composite of other contributors to the science that brought this enzyme therapy through the process. We had the opportunity to make him up out of those things that helped tell the story. We wanted to create both ally and antagonist for John [in the Extraordinary measures].

Never again will I allow our political self-interest to deter us from doing what we know to be morally right. Atrocity and terror are not political weapons. And to those who would use them, your day is over. We will never negotiate. We will no longer tolerate and we will no longer be afraid. It's your turn to be afraid.

I'm quite curious and excited about seeing a new script for 'Blade Runner.' If, in fact, the opportunity would exist to do another, if it's a good script, I would be very anxious to work with Ridley Scott again; he's a very talented and passionate filmmaker. And I think it would be very interesting to revisit the character.

I prefer to be part of a positive statement. I'm not interested in the psyche of a serial killer. What I'm interested in is creating a situation in which people get some emotional exercise, which makes them feel like human beings and makes them understand that they are part of the human community with all its responsibilities.

I think American films right now are suffering from an excess of scale. Lots of movies we're seeing now are more akin to video games than stories about human life and relationships. Twelve- to 20-year-olds are maybe the largest economic force in the US movie business. I'm not a very nostalgic person - but I enjoy a good story.

On the first 'Indiana Jones' movie, I tore an ACL in one of my knees - can't remember which knee. The scene in which I was fighting the big German mechanic on an airplane called a flying wing, I was run over by the landing gear and injured my knee, but I can't remember which one it was. Lots of bumps and injuries along the way.

The trick of this thing and the beauty of this thing is that it's a cowboy movie first and then stuff happens. Even after stuff happens it doesn't change - it hasn't suddenly changed into another kind of movie. It's still a cowboy movie. And that's what's incredible about it because nobody has done that before, that's new territory.

When I was a carpenter, I once worked with this Russian lady architect. I would tell her, ‘Look, I’m terribly sorry, but I want to change that a half inch,’ and she would say, ‘No limit for better.’ I think that is a worthy credo. You keep on going until you get it as close to being right as the time and patience of others will allow.

I went down to Venezuela and ended up renting a helicopter and flew with my sons to the tops of the tepuis, these freestanding jungle mesas, 'lost worlds' as it were. In fact, it's almost impossible to access them without one. So we were able to land and spend some time there. We were trapped for about six hours by clouds that came in.

What is news? It's hard to quantify. Certainly news has changed completely, and the morning shows are not really designed to bring you the news, except to tell you what happened overnight, and the rest of it is a kind of magazine mentality - a little bit of this, a little bit of that. It's harder to be an educated and informed citizen.

I think that the best movies are made, not from a point of view that depends on your personal history, whether it's the color of your skin or the politics that you had or the place that you come from, but from a point of view of an understanding of human nature, an understanding of history, and an understanding of what motivates people.

I get an opportunity to communicate with the audience about the movie that I've made. I get the chance to bring attention to the film that I've made. I care a lot about the movies that I make. I want them to reach an audience, and I want them to be successful. I promote nearly everything that I do, unless I've got some bad taste in my mouth.

I don't want to be a slave to electronic devices. I don't want to be connected to my friends. I don't want to send snapshots of my dog and cute pictures of my family life to my friends and family. I don't want to be liked, by pushing a button. I use all of this technology to basically replace devices that I had in the past which worked just fine.

With the CGI, suddenly there's a thousand enemies instead of six - the army goes off into the horizon. You don't need that. The audience loses its relationship with the threat on the screen. That's something that's consistently happening and it makes these movies like video games and that's a soulless enterprise. It's all kinetics without emotion.

I was desperately unhappy with it [Blade Runner]. I was compelled by contract to record five or six different versions of the narration, each of which was found wanting on a storytelling basis. The final version was something that I was completely unhappy with. The movie obviously has a very strong following, but it could have been more than a cult picture.

[After playing Indiana Jones and Han Solo] hero image concerns me a little, though not for my sake. All it means to me is that I have a responsibility not to get caught doing anything terrible and thereby jeopardise my credentials. Not that I do terrible things, like running over dogs or anything like that. It just makes you think twice before you say or do things in public.

We have been led to believe that we have come a long way toward world nuclear disarmament. But that is not the case. Our government is not doing all that it could. We must urge our leaders to fulfill the obligations of the Nuclear Non-Proliferation Treaty. The United States must assume world leadership to end once and for all the threat of nuclear war. It is our moral responsibility.

An icon means nothing to me. I don't understand what it means to anybody actually. It seems like a word of convenience. It seems to attend to the huge success of certain kinds of movies that I did, but there's no personal utility in being an icon. I don't know what an icon does, except stand in a corner quietly accepting everyone's attention. I like to work, so there's no utility in being an icon.

As a matter of fact, that was a bit of a problem for me at the beginning of my career - the problem of identification. In The Conversation I played a character who was gay, so nobody recognised me from American Graffiti. When I did Apocalypse Now, after Star Wars, I played an intelligence officer of the American army. George Lucas saw the footage I had done and didn't recognise me until halfway through the scene.

I have children. I have other concerns. I have other focuses. I really feel very sympathetic and I would love to be able to help but I don't see this as the opportunity, having done 'Extraordinary measures', for me to suddenly leap on a soap box and begin to talk about the pharmaceutical industry or the desperate plight of sick children. I do what I can in my world but I don't have the bona fides to do that right now.

There comes a point when you've exhausted your opportunities playing good guys. I've been around long enough, I think I'm entitled to explore a bit. But what I saw there was an opportunity to play a character different from what the audience's expectation was. A chance to take their crude experience of me - of my iconography, if you will - and turn it on its ear at an appropriate juncture in the film to be useful to the process of telling the story.

When we were making it [Star Wars], none of the effects were in. So the first time, I thought it was, you know, that - I mean, we were surrounded by English crew members that could hardly keep themselves together. They were, "Here comes the guy in the dog suit." They made fun of us, which was OK. But the first time I was sitting in a theater, and I saw all the effects in, and the big ship flew over the audience, and the sound rumbled, I pretty much thought we were close to home.

I have the ordinary experience of having the blender bottom come off in my room upstairs. I have the ordinary experience of being anonymous when I'm in an airplane talking to air-traffic control, and they don't know who they're talking to. I have a lot of common experiences. What's important is to be able to see yourself, as having commonality with other people and not determine, because of your good luck, that everybody is less significant, less interesting, less important than you are.

The capacity to create [visual] effects in the computer has made the job easier, but it has also introduced the complexity that you can with a few more keystrokes generate such a busy canvas that the eye doesn't know where to go. You lose human scale on an event and you're just wowed by the kinetics and the visualization. But, often in those cases I feel you lose touch with the human characters and what it is that they would feel and how they might feel, and that's still the most important part.

American Graffiti was the first movie where the director let me have any input. It was the first time anyone ever listened to me. George thought my character should have a crew cut, but I wasn't happy with that idea. I'd always had pretty long hair back then - in college, particularly - so I told George my character should wear a cowboy hat. George thought about it and he remembered a bunch of guys from Modesto, California, who cruised around, like my character, and wore cowboy hats, so it turned out that it actually fit the movie.

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