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If all other risk factors are normal, and you exercise moderately, your risk of having high CRP is one in 2000, .. A person who is a little overweight, with blood fats and cholesterol a little elevated, maybe with a little bit of high blood pressure -- we didn't used to think that having several of these little risk factors were a big deal. But it is. These little risk factors add up in a way that is worse for you than one big risk factor.