I spent two years in Cairo, and I felt a certain urgency about trying to understand the region and the conflict here, in the modest way that a journalist might be able to try and shed some understanding and enlightenment on a region that is profoundly conflicted, and a conflict that has real consequences for Americans.

I learned so much in Zimbabwe, in particular about the need for humility in our ambition to extend mental health care in countries where there were very few psychiatrists and where the local culture harboured very different views about mental illness and healing. These experiences have profoundly influenced my thinking.

Today, the world is so awash in sugar - it is such a staple of the modern diet, associated with all that is cheap and unhealthy - that it's hard to believe things were once exactly the opposite. The West Indies were colonized in a world where sugar was seen as a scarce, luxurious, and profoundly health-giving substance.

These technologies can make life easier, can let us touch people we might not otherwise. You may have a child with a birth defect and be able to get in touch with other parents and support groups, get medical information, the latest experimental drugs. These things can profoundly influence life. I'm not downplaying that.

Every major technological step forward has profoundly changed human society - that's how we know they're major, even if we don't always realise it at the time. Farming created cities. Writing, followed eventually by printing, vastly increased the preservation and transmission of cultural information across time and space.

I have a very personal feeling about how special America is, and I know how precious freedom is. It is a sacred gift, sanctified by those who have lived it and those who have died defending it. My right to speak my mind, to have a voice, to be what some have called 'opinionated,' is a right I deeply and profoundly cherish.

The general public, formerly profoundly indifferent to everything to do with building, has been shaken out of its torpor; personal interest in architecture as something that concerns every one of us in our daily lives has been very widely aroused; and the broad line of its future development are already clearly discernible.

In June 2010, after more than 38 years in uniform, in the midst of commanding a 46-nation coalition in a complex war in Afghanistan, my world changed suddenly - and profoundly. An article in 'Rolling Stone' magazine depicting me, and people I admired, in a manner that felt as unfamiliar as it was unfair, ignited a firestorm.

I try and write a fair amount in the beginning without the movie. And then when I do get the movie I create these demos, just mock-ups, and I throw them up against the picture and some of it sticks and some of it doesn't. But I'm very careful before I play anything to picture, because that's such a profoundly important moment.

George Bush ran a campaign where he bragged about being an anti-intellectual, dismissing his Harvard and Yale pedigree, pretending he was an American every day, ordinary everyman, and as a result of that, played up his fumbling speech because it signified that he was a good guy. That is deeply and profoundly anti-intellectual.

As life forms, viruses are just inherently interesting. It's the microworld - this universe of life too small for us to see - but it's profoundly complicated, and immensely powerful. Ebola is like a beautiful and frightening predator. There is a wonder in the operations of nature that can't be denied, even when we're the losers.

That part of Christ's nature which was profoundly human helps us to understand him and love him and to pursue his Passion as though it were our own. If he had not within him this warm human element, he would never be able to touch our hearts with such assurance and tenderness; he would not be able to become a model for our lives.

You start noticing that people are noticing how you look, and it is a profoundly alienating experience when it first happens, where you go on TV and you say something about some topic of the day, and on the Internet people are like, 'What was up with that shirt?' 'What was up with your hair?' And you think, 'Oh, that's kind of a bummer.'

In my mind, depression is, like all non-communicable diseases, a physiologically expressed condition which is profoundly influenced by our social and cultural environments. Depression is a global crisis not only because it is common and universal, but because the vast majority of affected people suffer in silence or receive inappropriate care.

My mother has always instilled in us that we should carry ourselves with dignity despite the horror that came with the civil war. She also taught us that where you come from is very important because that's what makes you who you are. So for me, whatever I've gone through had profoundly shaped me; it has given me strength and unwavering faith.

Sketching in general - anywhere, not just in Gitmo, but in life, in the world - is a profoundly disruptive act. Because you're creating something when you're kind of expected to consume or sit passively. I've always sketched things as a way to get into them, whether it was a fancy nightclub or, you know, to have kids think I was cool, whatever.

I'm the guy that has written at great length about exactly how we should profoundly reform Social Security. If I were afraid of going after entitlements, I wouldn't have done that, I wouldn't have put Medicaid reform in this budget, I wouldn't have called for the reductions in spending, which people will scream about, but I think are necessary.

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