Medicine is so big and so important.

We need to be humble in the face of uncertainty

The baseball draft is very different from the NBA or the NFL.

I have a little experience in doing things that are unpopular.

Cleveland and football have always held a special place in my heart.

Oftentimes the easy decision and comfortable decision is not the right one.

Baseball ultimately is a drama without a script. It's the original reality TV.

Scouts, by and large, are very industrious, very passionate and very loyal guys.

I played football in college and what I really wanted to do was be a football coach.

Circumstances change and you have to be proactive about changing with those circumstances.

We have to make judgments on the individual players and we're not always going to be right.

Analytics is not about sitting behind a computer and pushing enter and having it produce an answer.

A philosophy is important so that everyone is on the same page and there's a consistency of message.

If you have to remind people you're the boss, I don't think you're going to be a very effective leader.

There aren't 32 of them in the world that I think can be quarterbacks of Super Bowl champion teams. Supply is short.

In a given year, there may be two or three NFL-ready quarterbacks at the college level. In another year, there literally may be zero.

There probably isn't another position in all of team sports that I can think of that has the same level of import as the quarterback.

I think the hardest part, and where we have to stay the most disciplined, as much as you want a player, you can't invent him if he doesn't exist.

In disciplines as disparate as baseball, financial services, trucking and retail, people are realizing the power of data to help make better decisions.

It's one thing to be able to analyze something. It's another to implement it or execute on a vision or even to get a whole bunch of people to rally behind it.

Admittedly, there will be an awful lot for me to learn, but I want nothing more than to help bring consistent, championship caliber football back to Cleveland.

The nice thing about baseball is that all of the possible outcomes are known - it's not quite as messy as the real world. That makes the game an excellent playground for probability.

Moneyball' doesn't have anything to do with on-base percentage or statistics. It's a constant investigation of stagnant systems, to see if you can find value where it isn't readily apparent.

If I play my home games in Coors Field, I'm probably not going to be doing a whole lot of bunting. If I play my home games in Petco Park or Dodger Stadium, it's probably going to be a more valuable tool.

Whether baseball or football, we're tasked in front offices with making decisions under uncertainty. How do you corral that uncertainty in a way to make more consistently better decisions? That's very similar.

That's sort of my mindset, more than anything else, whenever I get into anything new. I'm in this constant pursuit for new knowledge. I think I sometimes focus more on all the things that I don't know and what I'm trying to figure out.

I really focus on process as much as anything else: process for how we evaluate players, process for how we make decisions, process even for how we hire people internally, process for how we go about integrating our scouting reports with guys watching tape in the office.

I think there are definitely things over the last year-and-a-half we would have done differently, ... I think we've at least learned as we go and hopefully we don't make the same mistake next time. ... I think if I said anything different to you, I'd be removed from reality.

I was well aware of my limitations as a football player and knew that I needed every edge I could possibly get in order to compete. A big part of that was to be as precise as I could and make as few mistakes as possible because I figured that was the only way I could survive.

Are there things you can do with the rest of your personnel or are things you can do schematically to help a quarterback? I think so. But at the end of the day, that quarterback still has to be a driving force of your team, especially if you want to be a consistent winner over time.

The A's were a team with very few resources. We didn't have access to players who were obviously great, who could do it all and were always in the headlines. We couldn't afford those types of players. So we had to figure out a way of cobbling together players into a team that might be competitive.

I got into baseball, and everyone just started calling me a geek, like, 'There's the nerd from Harvard.' Then it took 20 years of working in baseball and me actually leaving and going to football for people to say, 'He's the baseball guy.' So maybe at some point I'll be known as a football guy too.

As the West Coast offense has spread out among the NFL, as all of Bill Walsh's assistants and all of Mike Holmgren's assistants have gone on to be head coaches, it's all the West Coast offense, but it's all a little different, tailored to the personnel or the coordinators or the resources each team has.

There are a lot of parallels between being a mutual fund manager and being a general manager. Both in the financial markets and in baseball, we're dealing with a world where uncertainty reigns. We're trying to predict the future performance of human beings. It's a fundamental difficulty for which we both have to account.

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