If somebody is working on a new medicine, computer science helps us model those things. We have a whole group here in Seattle called the Institute for Disease Modelling that is a mix of computer science and math-type people, and the progress we're making in polio or plans for malaria or really driven by their deep insights.

Most innovations, unfortunately, actually increase the net costs of the healthcare system. There's a few, particularly having to do with chronic diseases, that are an exception. If you could cure Alzheimer's, if you could avoid diabetes - those are gigantic in terms of saving money. But the incentive regime doesn't favor them.

Software substitution, whether it's for drivers or waiters or nurses ... it's progressing. ... Technology over time will reduce demand for jobs, particularly at the lower end of skill set. ... 20 years from now, labor demand for lots of skill sets will be substantially lower. I don’t think people have that in their mental model.

This is something we're very committed to, it's something that I think people are underestimating right now as they've seen some of the dot-com promises not come through. I think they're missing the fact that the basic technology is moving forward, the new platforms are here and this vision of the digital decade will be a reality.

Software is inherently complicated. If you say to somebody I want an airline reservation system, to really say what you want in terms of overbooking and fares, and different airlines communicating with each or schedule changes, it's immensely complex. And so you can't write a program that's any simpler than that full specification.

I try to make time for reading each night. In addition to the usual newspapers and magazines, I make it a priority to read at least one newsweekly from cover to cover. If I were to read what intrigues me- say, the science and business sections - then I would finish the magazine the same person I was when I started. So I read it all.

There are several hundred people who stayed in the Ebola-affected countries and continued to do the work, put themselves at great risk because medical workers are the most likely to be infected because they're helping out when the person's health is deteriorating, including quite a bit of bleeding as they're getting very, very sick.

I actually thought that it would be a little confusing during the same period of your life to be in one meeting when you're trying to make money, and then go to another meeting where you're giving it away. I mean is it gonna erode your ability, you know, to make money? Are you gonna somehow get confused about what you're trying to do?

By the time we see that climate change is really bad, your ability to fix it is extremely limited... The carbon gets up there, but the heating effect is delayed. And then the effect of that heat on the species and ecosystem is delayed. That means that even when you turn virtuous, things are actually going to get worse for quite a while.

I am surprised that in various countries, whether it's the U.K. or the U.S., you see isolationist tendencies that would tend to work against the co-operation, whether it's climate change, immigration, innovation, helping the very poorest. Those are things where you want to think across country boundaries and see a win-win-type solution.

I was announcing to the public, in 2006, that I'd be leaving Microsoft in a couple of years and focusing full-time on the foundation. That was the time at which we went back to New York and Warren [Buffett] announced these gifts to a number of foundations, with a very high percentage of it going to us and basically doubling our capacity.

The Center for Disease Control started out as the malaria war control board based in Atlanta. Partly because the head of Coke had some people out to his plantation and they got infected with malaria, and partly cause all the military recruits were coming down and having a higher fatality rate from malaria while training than in the field.

At some point, that risk-taking private capital can take over, and have patents and trade secrets and things that let them lead the way, which happened with the steam engine and some other things, although with energy, the time of adoption is a lot longer than it is with, say, IT products or even medical advances, like drugs and vaccines.

We can make market forces work better for the poor if we can develop a more creative capitalism-if we can stretch the reach of market forces so that more people can make a profit, or at least make a living, serving people who are suffering from the worst inequities. ... You have more than we had; you must start sooner, and carry on longer.

The first big effects will be farmers that live on the edge. Today's weather, they barely get by. Their kids, a high percentage are malnourished, and so if you impose more variable weather and more heat, you're getting more floods, more droughts, and during the germination time, the high heat, most crops...do poorly when there's more heat.

One of the statistics that always amazes me is the approval of the Chinese government, not elected, is over 80 percent. The approval of the U.S. government, fully elected, is 19 percent. Well, we elected these people and they didn't elect those people. Isn't it supposed to be different? Aren't we supposed to like the people that we elected?

The media covers what’s new – and millions of people dying is nothing new. So it stays in the background, where it’s easier to ignore. But even when we do see it or read about it, it’s difficult to keep our eyes on the problem. It’s hard to look at suffering if the situation is so complex that we don’t know how to help. And so we look away.

The Center for Disease Control started out as the malaria war control board based in Atlanta. Partly because the head of Coke had some people out to his plantation, and they got infected with malaria, and partly 'cause all the military recruits were coming down and having a higher fatality rate from malaria while training than in the field.

We're still missing about a dozen vaccines that will make a huge difference. For adults, we've got HIV and TB are still huge; for kids malaria is still killing a half million kids a year out of that 6 million. We probably need some vaccines, but we need a little more data to make sure we're getting the vaccines that will save the most lives.

I think we knew that this would be just like raising the kids together, this would be a fun thing to do in partnership. And you know, we're so lucky because we get to hire in very smart people. We get to partner with governments like the Canadian Development Organization - CIDA, USAID - tonnes of scientists doing this work. This is fascinating.

I believe that the world will be a safer place if there is enough food to go around, that it will be a more stable place if children grow up with opportunities instead of frustrations. Furthermore, I can only assume that if the United States plays a role in helping to create prosperous societies, we will have friends to call on in times of need.

The genius of capitalism lies in its ability to make self-interest serve the wider interest. The potential of a big financial return for innovation unleashes a broad set of talented people in pursuit of many different discoveries. This system, driven by self-interest, is responsible for the incredible innovations that have improved so many lives.

Contrary to Piketty’s rentier hypothesis, I don’t see anyone on the [Forbes 400 list of the wealthiest Americans] whose ancestors bought a great parcel of land in 1780 and have been accumulating family wealth by collecting rents ever since. In America, that old money is long gone - through instability, inflation, taxes, philanthropy, and spending.

Anyway, the US, as in most issues, is the best, has the best capability to lead, and really needs to lead. It doesn't [mean] that other countries won't pick different tacks and emphasize different things. In aggregate, they're almost half of the energy R&D. Europe, China, Japan - it's very important that they come along and contribute to these things.

The only role other than paying their taxes, whatever those are, the only role for philanthropy broadly - of which the rich should give disproportionately - the more, the better - and I think there is a positive trend in that direction - there are certain risk-taking things, like trying out a new type of charter school or funding a new kind of medicine.

We all learn best in our own ways. Some people do better studying one subject at a time, while some do better studying three things at once. Some people do best studying in structured, linear way, while others do best jumping around, surrounding a subject rather than traversing it. Some people prefer to learn by manipulating models, and others by reading.

The general idea of the rich helping the poor, I think, is important. That your sense of justice says, why should rich kids - who barely get these diseases and almost never die of them - why should they get the vaccines, when poor kids, who actually do die from these diseases, don't get those things? It's an unbelievable inequity that there isn't that access.

I think if you talk to the experts in any field where you have to take on a unknown challenge, where you're going to be working on it for a long time you'd find that to work themselves up to their best performance and really throw themselves into it, you know, spend all these hours in there and ah, give it their... give it their best that optimism plays a role.

Cutting through complexity to find a solution runs through four predictable stages: determine a goal, find the highest-leverage approach, discover the ideal technology for that approach, and in the meantime, make the smartest application of the technology that you already have - whether it's something sophisticated, like a drug, or something simpler, like a bednet.

So on the demand side [for energy], there have been a variety of policies that globally have been way over $50 billion a year of tax credits, raising the price of electricity through things like renewable portfolio standards, so the total amount of money that's gone into sending a price signal to push up demand versus what would happen without it has been gigantic.

Online education is pretty special for two reasons. One is that you can get the very best lecture in the world and wherever you are, whenever you want, you can connect to that lecture. The other is this interactivity, where if you know a topic, you can kind of skip over it. Or if you're confused about it, [the area] where you're confused can be analyzed by software.

The US in some ways has been the best. Who figured out shale gas? Although that wasn't a good thing [for CO2 levels], it was very innovative. It's led to low-cost energy. Who figured out nuclear power? Largely the United States. Once you get past the steam engine, which is mostly British, then the US has been at the center of most of the energy things that have happened.

The most straightforward path would be if we could bring the cost of solar electric and wind down by another factor of say, three, and then have some miraculous storage solution, so that not only over the 24-hour day but over long periods of time where the wind doesn't blow, you have reliable energy. That's a path. But energy storage is hard. That's not a guaranteed path.

So it's an absolute lie that has killed thousands of kids. Because the mothers who heard that lie, many of them didn't have their kids take either pertussis or measles vaccine, and their children are dead today. And so the people who go and engage in those anti-vaccine efforts -- you know, they, they kill children. It's a very sad thing, because these vaccines are important.

If your goal is to make the world a better place, one thing you can do is pick a specific challenge that you really care about. Then, learn as much as you can about it and try to volunteer your time to help an organization that is working in this area. While you're doing that, look for creative new ways to use technology to tackle parts of the problem that you come in contact with.

Vaccines are a miracle; they're fantastic. Anything that makes people hesitate to give their children these vaccines according to the recommended schedule creates risk. Risk for the children who don't get vaccinated and risk for children, some of whom don't have an immune system, so they're benefiting from the fact that the community protection means the disease doesn't get to them.

Well, jobs are a great thing. You have to be a bit careful: If you raise the minimum wage, you’re encouraging labor substitution and you’re going to go buy machines and automate things - or cause jobs to appear outside of that jurisdiction. And so within certain limits, you know, it does cause job destruction. If you really start pushing it, then you’re just making a huge trade-off.

If somebody is considering being willing to go out and work in the field in global health, those are a particular class of heroes because it's hard to work in those places. Our foundation gets so many of our learnings from people who've been out there and seen, "this tool is not going to work there, there's more of a problem here than you know." You should really get involved in that.

I admire leaders in science, people who really figure things out like Richard Fineman or people who work on vaccines, tons of people working on [the] HIV vaccine. There's leaders in business, people like Warren Buffett, who've got a certain approach they take that are pretty amazing. There [are] product innovators like Steve Jobs was, where he gets behind a concept and does a fantastic job.

I do normal kind of contributions, particularly for people who are going over to Africa and help highlighting global health, and that's tended to be pretty bipartisan in nature because of the coalition there exists fortunately around these global health issues. But I don't think my backing, putting a lot of money into political contributions is a way I'm going to try and help improve the world.

These four policy prescriptions - strengthening educational opportunities, revamping immigration rules for highly skilled workers, increasing federal funding for basic scientific research, and providing incentives for private-sector R&D - should in my view be top priorities as Congress and the Administration consider how to maintain the nation's leadership in science, technology, and innovation.

We're creating this alliance, GAVI, that has helped buy the vaccines that were in the rich world but not getting to the poor kids, getting a very cheap price and figuring out the cold chain, getting the delivery right, and then funding research for new vaccines. A lot of them are coming along. We've got a meningitis vaccine out, got that through large parts of Africa. That has been a huge success.

Sometimes we do get taken by surprise. For example, when the Internet came along, we had it as a fifth or sixth priority. It wasn't like somebody told me about it and I said, "I don't know how to spell that." I said, "Yeah, I've got that on my list, so I'm okay." But there came a point when we realized it was happening faster and was a much deeper phenomenon than had been recognized in our strategy.

When you develop software, the people who write the software, the developers are the key group but the testers also play an absolutely critical role. They're the ones who ah, write thousands and thousands of examples and make sure that it's going to work on all the different computers and printers and the different amounts of memory or networks that the software'11 be used in. That's a very hard job.

One thing people underestimate is how markets don't allow anyone to do anything except make better and better products. There's not much leeway. The world is a lot more competitive than most people think, particularly in a high-technology area. If a company takes its eye off improving its products, if it tries to do anything that would be viewed as an exercise of power, it'll be displaced very rapidly.

Hopefully, whether it's energy or child vaccines, the case of the many benefits helping countries so that they are stable, so these refugee problems that have been troubling for Europe - a little less so for the U.S. but, even so, a lot of controversy there - these things are why the future's going to be better than the past. People really do look to the United States, so we'll be there making the case.

Depending on how quickly you get ocean rise, you have people who live in river deltas [at risk]. Bangladesh is largely a river delta, and the rising sea level means that when storms come in, the human sanitation is backing up, the ability to farm, it's destructive-type situations like you saw in New Orleans with Katrina. You're increasing the frequency of that stuff in low-lying areas fairly dramatically.

The challenge here is to design a system where market incentives, including profits and recognition, drive those principles to do more for the poor. I like to call this idea creative capitalism, an approach where governments, businesses, and nonprofits work together to stretch the reach of market forces so that more people can make a profit, or gain recognition, doing work that eases the world's inequities.

When you say that after World War I there was a pandemic that killed more people than the war itself, most will say: "Wait, are you kidding? I know World War I, but there was no World War 1.5, was there?" But people were traveling around after the war, and that meant the force of infection was much higher. And the problem is that the rate of travel back then was dramatically less than what we have nowadays.

Unfortunately, in rich-world health, innovation is both your friend and your enemy. Innovation is inventing organ replacement, joint replacement. We're inventing ways of doing new things that cost $300,000 and take people in their 70s and, on average, give them an extra, say, two or three years of life. And then you have to say, given finite resources, should we fire two or three teachers to do this operation?

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