Quotes by Charles Jules Henry Nicole - Page 1

It did not seem likely that I was destined to undertake research on typhus.
Charles Jules Henry Nicole /
Destined
Research
Typhus
Likely
Seem
Undertake
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I finally demonstrated that typhus infection is not hereditary in the louse.
Charles Jules Henry Nicole /
Hereditary
Infection
Typhus
Finally
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Most of the doctors in the Tunisian administration, especially those in country districts, contracted typhus and approximately one third of them died of it.
Charles Jules Henry Nicole /
Administration
Died
Doctors
Typhus
Approximately
Contracted
Districts
Third
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Of all the problems which were open to me for study, typhus was the most urgent and the most unexplored. We knew nothing of the way in which contagion spread.
Charles Jules Henry Nicole /
Contagion
Spread
Study
Typhus
Unexplored
Urgent
Me Problems Way
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The fact that I was fortunate enough to escape contagion, in spite of frequent, sometimes daily contacts with the disease, was because I soon guessed how it spread.
Charles Jules Henry Nicole /
Disease
Fortunate
Spite
Spread
Contacts
Daily
Escape
Frequent
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At the time when I was conducting my research there was no known method for taking the guinea pig's temperature. I demonstrated a technique which is now widely used.
Charles Jules Henry Nicole /
Conducting
Guinea
Method
Research
Technique
Temperature
Pig
Widely
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The discovery that I soon made that the guinea pig was also susceptible to infection made it possible for me, from the third year on, to preserve the virus on this animal.
Charles Jules Henry Nicole /
Animal
Discovery
Guinea
Infection
Susceptible
Guinea Pig
Pig
Preserve
Third
Virus
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I was less successful in my attempts to effect preventive vaccination against typhus by using the virus and in trying to produce large quantities of serum using large animals.
Charles Jules Henry Nicole /
Produce
Successful
Typhus
Animals
Attempts
Effect
Large
Preventive
Quantities
Vaccination
Virus
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My first attempts to transmit typhus to laboratory animals, including the smaller species of monkeys, had failed, as had those of my predecessors, for reasons which I can easily supply today.
Charles Jules Henry Nicole /
Including
Laboratory
Monkeys
Predecessors
Species
Transmit
Typhus
Animals
Attempts
Easily
Failed
Reasons
Smaller
Supply
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From the practical point of view, the susceptibility to infection of the guinea pig proved to be the most useful step forward. Today, all laboratories use this animal for preserving the virus.
Charles Jules Henry Nicole /
Animal
Guinea
Infection
Point Of View
Useful
Guinea Pig
Pig
Practical
Preserving
Proved
Step Forward
Virus
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Even if it had not been possible to reproduce the disease in animals and consequently to verify the hypothesis, this simple observation would have been sufficient to demonstrate the way in which the disease was propagated.
Charles Jules Henry Nicole /
Disease
Hypothesis
Observation
Sufficient
Verify
Animals
Consequently
Demonstrate
Reproduce
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I demonstrated the characteristics of experimental fever. It appears after an incubation period which is never less than five days. It follows the same pattern as natural fever in man, but is of shorter duration and less pronounced.
Charles Jules Henry Nicole /
Characteristics
Duration
Fever
Appears
Period
Follows
Pattern
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Just as the only reservoir for the typhus virus in nature is provided by man, so the only vector of infection is the louse. The bite of the louse is not virulent immediately after the infecting meal. It becomes so only towards the 7th day following infection.
Charles Jules Henry Nicole /
Following
Infection
Typhus
Bite
Towards
Immediately
Meal
Provided
Reservoir
Virus
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Charles Jules Henry Nicole Quotes - Page 1

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