It is when physicians are bogged down by their incomplete technologies, by the innumerable things they are obliged to do in medicine when they lack a clear understanding of disease mechanisms, that the deficiencies of the health-care system are most conspicuous. If I were a policy-maker, interested in saving money for health care over the long haul, I would regard it as an act of high prudence to give high priority to a lot more basic research in biologic science.

Exclamation points are the most irritating of all. Look! they say, look at what I just said! How amazing is my thought! It is like being forced to watch someone else's small child jumping up and down crazily in the center of the living room shouting to attract attention. If a sentence really has something of importance to say, something quite remarkable, it doesn't need a mark to point it out. And if it is really, after all, a banal sentence needing more zing, the exclamation point simply emphasizes its banality!

The commas are the most useful and usable of all the stops. It is highly important to put them in place as you go along. If you try to come back after doing a paragraph and stick them in the various spots that tempt you you will discover that they tend to swarm like minnows into sorts of crevices whose existence you hadn't realized and before you know it the whole long sentence becomes immobilized and lashed up squirming in commas. Better to use them sparingly, and with affection, precisely when the need for each one arises, nicely, by itself.

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