The pure culture is the foundation for all research on infectious disease.

From my numerous observations, I conclude that these tubercle bacilli occur in all tuberculous disorders, and that they are distinguishable from all other microorganisms.

Our studies have shown that all cases of typhoid of this type have arisen by contact, that is, carried directly from one person to another. There was no trace of a connection to drinking water.

In view of the epidemiological situation in Germany, the lack of evidence for the effectiveness of the BCG-vaccine and the not uncommen severe, undesired side-effects of the BCG vaccine, the STIKO can no longer support the recommendation for this vaccination.

However, on many occasions, I examined normal blood and normal tissues and there was no possibility of overlooking bacteria or confusing them with granular masses of equal size. I never found organisms. Thus, I conclude that bacteria do not occur in healthy human or animal tissues.

If my efforts have led to greater success than usual, this is due, I believe, to the fact that during my wanderings in the field of medicine, I have strayed onto paths where the gold was still lying by the wayside. It takes a little luck to be able to distinguish gold from dross, but that is all.

... After it has been determined that the pathogenic organism is present in the animal body, and after it has been shown that the organism can reproduce in the body and be transmitted from one individual to another, the most important experiment remains to be done....to determine the conditions necessary for growth and reproduction of the microorganism.

To prove that tuberculosis is caused by the invasion of bacilli, and that it is a parasitic disease primarily caused by the growth and multiplication of bacilli, it is necessary to isolate the bacilli from the body, to grow them in pure culture until they are freed from every disease product of the animal organism, and, by introducing isolated bacilli into animals, to reproduce the same morbid condition that is known to follow from inoculation with spontaneously developed tuberculous material.

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