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If you don't have negative experiences, you have no way to gauge the positive ones, and you have no way to deal with it.
If I had my way, I wouldn't do annual reviews, if I felt that everybody would be more honest about positive and negative feedback along the way. I think the annual review process is so antiquated.
I feel ups and downs are a part of one's career, and this totally depends on how you take it. You can either be knocked down by the negative things, or you can take it in a positive way and learn from it.
In the tissues generally, and in such a cavity as the abdomen, the pressure is everywhere and practically always very nearly atmospheric, and must be so, because the integuments give way very easily to any excess of pressure, whether positive or negative.