I'm coming back in... and it's the saddest moment of my life.

The Shuttle is to space flight what Lindbergh was to commercial aviation.

History will remember the twentieth century for two technological developments: atomic energy and space flight.

By the way, Japan is also known to be actively engaged in manned space flights as part of the International Space Station.

To be the first to enter the cosmos, to engage, single-handed, in an unprecedented duel with nature-could one dream of anything more?

Of course risk is part of spaceflight. We accept some of that to achieve greater goals in exploration and find out more about ourselves and the universe.

Space flights are merely an escape, a fleeing away from oneself, because it is easier to go to Mars or to the moon than it is to penetrate one's own being.

NASA was going to pick a public school teacher to go into space, observe and make a journal about the space flight, and I am a teacher who always dreamed of going up into space.

The single simplest reason why human space flight is necessary is this, stated as plainly as possible: keeping all your breeding pairs in one place is a retarded way to run a species.

Retain the vision for space exploration. If we turn our backs on the vision again, we're going to have to live in a secondary position in human space flight for the rest of the century.

Basically, most good science in space flight has to do with the behavior of the human body in space. That is where we are lacking info, and where info can only be obtained by flying in space.

I would say keep supporting space flight, keep telling the public and the politicians why it's important to advance science and explore the galaxy. I encourage the Japanese to keep doing what they're doing.

I am excited to think that the development of commercial capabilities to send humans into low Earth orbit will likely result in so many more Earthlings being able to experience the transformative power of space flight.

With our present knowledge, we can respond to the challenge of stellar space flight solely with intellectual concepts and purely hypothetical analysis. Hardware solutions are still entirely beyond our reach and far, far away.

And from, you know, small ideas, bigger ideas emerge. So we're starting with suborbital space flights and we'll then go into orbital space flights and, you know, maybe one day we'll send people on a one-way voyage into the depths of space as per the science fiction trips.

It was the time of the Cold War and so there were was a lot of pressure on the - to get going and the Russians were claiming that they were - Soviets were claiming they were ahead of us in technology. And so it was against that backdrop that the early space flights took off.

We collectively have a special place in our heart for the manned space flight program - Apollo nostalgia is one element, but that is only part of it. American culture worships explorers - look at the fame of Lewis and Clark, for example. The American people want to think of themselves as supporting exploration.

For the last several years and culminating in six months in orbit next year, I've been training for my third space flight. This one is almost in a category completely different than the previous two, specifically to live in on the space station for six months, to command a space ship and to fly a new rocket ship.

I'm somewhat antagonistic towards these various projects that charge $250,000 per person for the ability to be weightless for 3 minutes after being brought up from earth. I think there are such better uses for that money that i seriously question the ethics of spending hundreds of thousands of dollars on space flights for extremely wealthy people.

The urge to explore has propelled evolution since the first water creatures reconnoitered the land. Like all living systems, cultures cannot remain static; they evolve or decline. They explore or expire. . . . Beyond all rationales, space flight is a spiritual quest in the broadest sense, one promising a revitalization of humanity and a rebirth of hope no less profound than the great opening out of mind and spirit at the dawn of our modern age.

There's a huge amount of pressure on every astronaut, because when you get right down to it, the experiments that are conducted on a space flight, or the satellites that are carried up, the work that's to be done, is important and expensive work, and you are up there for a week or two on a Space Shuttle flight. The country has invested a lot of money in you and your training, and the Space Shuttle and everything that's in it, and you have to do things correctly. You can't make a mistake during that week or two that you're in space.

Other anatomical changes associated with long-duration space flight are definitely negative: the immune system weakens, the heart shrinks because it doesn't have to strain against gravity, eyesight tends to degrade, sometimes markedly (no one's exactly sure why yet). The spine lengthens as the little sacs of fluid between the vertebrae expand, and bone mass decreases as the body sheds calcium. Without gravity, we don't need muscle and bone mass to support our own weight, which is what makes life in space so much fun but also so inherently bad for the human body, long-term.

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