Even a single Justice can have a profound impact on the country.

Chuck Berry had a very profound impact on me. The man was a genius.

Living in South Africa has had a very profound impact on my career.

I went and saw Letterman when I was 15, and that had a profound impact on me.

BRICS meetings are keenly watched world over, and our decisions have profound impact globally.

My eyebrows make a more profound impact on other people than they do on me. I just let 'em grow.

Whether you reach a lot of people or have a profound impact on a few people, their memories of you are your afterlife.

My mother told me many stories about her childhood in Cuba. Living there had a profound impact on her and how she regards herself.

Global climate change has a profound impact on the survival and development of mankind. It is a major challenge facing all countries.

Catcher in the Rye had a profound impact on me-the idea that we all have lots of dreams that are slowly being chipped away as we grow up.

While having a profound impact on the development of values is surely an important job of a good parent, force-feeding opinions to them is not.

The progressive integration of new technologies in our economy amounts to a paradigm shift with a profound impact on the context and content of work.

Influential people have a profound impact on everyone they encounter. Yet, they achieve this only because they exert so much influence inside, on themselves.

I love heavy music, but you see, I had fallen in love with a radio station in Vegas that played nothing but Eighties music. That had a real profound impact on me.

I speak often about my personal experiences with malaria in the field as a young public health officer because it had such a profound impact on my life and my work.

People regard Yahoo as a platform for essential services, and it's had a profound impact on the way people obtain information, communicate, and their entertainment.

The growing professional disciplines of medical ethics and bioethics have had a profound impact on researchers, bedside doctors, associations of physicians, and government.

We know that the decisions we reach will have a profound impact on the communities hosting our military installations, and more importantly, on the people who bring those communities to life.

As a former CEO and senior executive, there was a time when I did not quite understand the profound impact a CEO has on the culture of a company, even though I always knew culture was important.

I started my career at General Electric in a small office under a guy named Greg Liemandt, and his direct boss was Jack Welch. I would say those two have had the most profound impact on my career.

My early comics are really reflective of being kind of a befuddled, single loser in the Bay Area, and I think having kids has been by far the most profound impact on me as a person and as an artist.

As prevalent as loneliness is, many people don't recognize that people that they know may very well be suffering from loneliness. It's important for many reasons, one of which is that it has a profound impact on health.

When you are finally in space and you're finally looking back at Earth and you realize for the first time in your life there's nothing standing between you and your dream, it's just so hard to describe the profound impact of that.

If I stayed a football player, my career would have been over 20 years ago. As it is, my knees are shot. I found I got the same good feeling in acting that I had in sports, but I found I could have a more profound impact on people.

Good is somebody who delivered and allowed the company to overcome obstacles, without leaving a profound impact on its culture. Great is somebody who leads his company to achievements and performance and value that nobody was expecting it had.

When you're talking with a person at this level of the government, at the very highest level, I think you have to be very discreet because he, President Clinton, is very aware that anything he says publicly can have a profound impact on American politics and on world politics.

My grandmother has dementia, and my mother is looking after her as her primary caregiver. Seeing their relationship has had a profound impact, seeing how tough it is for both of them and seeing how the roles change and how my mother has gone from being a daughter to being the mother.

I will talk about two sets of things. One is how productivity and collaboration are reinventing the nature of work, and how this will be very important for the global economy. And two, data. In other words, the profound impact of digital technology that stems from data and the data feedback loop.

Billy Graham is one of my great lifetime heroes. I think he epitomizes the essence of what a Christian leader should be. I have participated in some of his crusades a couple of times in Atlanta. I've seen the profound impact he's had on me personally, and on other people who were not Christians and accepted Christ as Savior.

Adults who loved and knew me, on many occasions sat me down and told me that I was black. As you could imagine, this had a profound impact on me and soon became my truth. Every friend I had was black; my girlfriends were black. I was seen as black, treated as black, and endured constant overt racism as a young black teenager.

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