Getting a traditional pharmaceutical to the market can cost a billion dollars or more. Newer, more tailored and targeted drugs called biologics are even more complex and expensive. Simple economics dictates that companies and venture funds will invest more in products that can generate a sufficient return.

Hedge funds try to produce above-average investment returns using tactics ranging from traditional stock-picking to complex derivative and arbitrage plays. High minimum investments, redemption restrictions and aggressive strategies make them suitable mainly for more sophisticated and well-heeled investors.

America faces a mounting transportation crisis, and the primary culprit is road congestion. Traffic makes us unhealthy, wastes enormous amounts of time, and cripples national productivity. America needs expanded roads and transportation infrastructure, but traditional gas tax funding is no longer available.

One of the most important things liberals don't understand about conservatism, obscured by too much lazy talk about conservatism's various 'wings,' is that its tenets form a relatively organic base for its adherents, where 'traditional morality' serves the interests of laissez-faire economics and vice-versa.

Traditionally, life has been divided into two main parts: a period of learning followed by a period of working. Very soon, this traditional model will become utterly obsolete, and the only way for humans to stay in the game will be to keep learning throughout their lives and to reinvent themselves repeatedly.

When I talk of primordial innocence, I hear it in Sufi music with the nay flute. I see it in Coptic icons, in most traditional art, particularly art of the American Indian. I find the texts extraordinarily beautiful and very childlike and very simple. I've been particularly interested in American Indian texts.

Mom still has a huge, beautifully decorated Christmas tree. The whole family comes together after midnight mass and has the traditional plum cake and wine. We spend the night at mom's home, and in the morning we wake up and open the presents. In the afternoon, we sit down to have a traditional Christmas lunch.

I have never made a cent off a record in my life. I have never recouped enough, and I never sold enough. When people see you have a song on MTV, they think you are doing well - but you know, the way the traditional label deal was set up, it is really hard for an artist, unless they sold a lot, to see anything.

I've worked in the Inuit hamlets of the west coast of Hudson Bay since 1994. Over that time I've been very moved by both the pace of social change there - the loss of traditional ways of seeing the world, the affinity for and comfort with the land - and by the social disarray that change of this pace produces.

We need to develop and disseminate an entirely new paradigm and practice of collaboration that supersedes the traditional silos that have divided governments, philanthropies and private enterprises for decades and replace it with networks of partnerships working together to create a globally prosperous society.

I have spent seven of the 12 years I have been married a victim of political persecution. I must be the first male spouse being held hostage by a regime. I accept this, as Pakistan has traditional elements who find it hard to reconcile with a man whose wife works and who other men salute perforce of her office.

From the time I left the Marine Corps after serving as an infantry platoon and company commander in Vietnam, I decided that I would focus on immediate goals that inspired me to devote all of my energy to them, rather than putting together the more cautious and traditional building blocks of a predictable career.

The traditional Hollywood system is pretty rigid, but the film scene in, say, South Africa is booming with a lot of possibilities. If you have the cameras and reasonable capital, you can put your film in theatres next to 'Guardians of the Galaxy.' A great example of that was Kagiso Lediga's film 'Blitz Patrole.'

It's time for male leaders to not only ask for binders of qualified women, but to re-write the definition of 'qualified.' The best man for the job, may in fact, be a woman, whose biography is not traditional, but is rich with experiences and skills that are not necessarily learned either in school or on the job.

ISIL's widespread reach through the Internet and social media is most concerning, as the group has proven dangerously competent at employing such tools for its nefarious strategy. ISIL uses high-quality, traditional media platforms as well as widespread social media campaigns to propagate its extremist ideology.

Every time I've done comedy in, like, traditional comedy clubs, there's always these comedians that do really well with audiences but that the other comedians hate because they're just, you know, doing kind of cheap stuff like dancing around or doing, like, very kind of base sex humor a lot, and stuff like that.

We have 11 great potato flavors, and customers have been clamoring for tortilla. For over a year, we worked to develop the four flavors of tortilla popchips: chili limon, nacho cheese, ranch and salsa. They're made with traditional stoneground masa, are gluten-free, and have less than half the fat of other chips.

I'm one of those people that thinks the world changes in smaller and in more mysterious ways than a lot of people like to think. A lot of traditional charities and organizations do things that on the surface seem like a good idea, but it doesn't change the way that people think about interacting with other people.

One thing that's a lot harder to put into stories than you'd think is the idea of a traditional monster, because monsters with a capital 'M' don't inherently lend themselves to a story about your character. Unless one of your characters is themselves the monster, simply having a monster leads to a chase or a hunt.

I think people are sort of waking up to it now, how probably the biggest change in Internet media isn't the immediacy of it, or the low costs, but the measurability. Which is actually terrifying if you're a traditional journalist, and used to pushing what people ought to like, or what you think they ought to like.

The rise of a ubiquitous Internet, along with 24-hour news channels has, in some sense, had the opposite effect from what many might have hoped such free and open access to information would have had. It has instead provided free and open access, without the traditional media filters, to a barrage of disinformation.

Lagos style is fresh and different. Even with the tailors, they get very innovative with their stuff, with the cuts. When my parents used to make the traditional wares, it was a little bit baggy. But now the tailors are able to infuse the European style, making it slim-fit. Lagos style is different, man. Innovative.

People don't realize that the Obama Administration has been, if anything, harder on whistleblowers than the Bush Administration. Part of the reason is that they know that the response will be more muted because the traditional constituency supporting whistleblowers just happen to be the same constituency as Obama's.

Growing up in Huntington Beach, you were either a traditional sports athlete, a skateboarder, or a surfer. I got my first skateboard when I was five and skated off and on over the years, did a little BMX racing as a kid, and then in my freshman or sophomore year I started getting a little bit more into skateboarding.

Digitization and new technologies are rapidly changing all industries, forcing them to prepare for a tomorrow that is unpredictable. This also applies to the industry of container shipping, ports, and logistics, which largely has been driven by the traditional business models focused on optimizing how you move goods.

I did have a nice career in print, but traditional publishers don't always have the resources to create individualized marketing for their authors. Mine never figured out how to package books as hot as mine so that they found their full audience. Finally, I got frustrated enough over my lack of traction to walk away.

Podcasting is not really that different from streaming music, which we've done for quite a long time. Having a traditional podcast that people subscribe to - the hype is ahead of the quality. Podcasting is essentially a download, and you run into copyright issues. What you're left with currently is podcast talk radio.

I sometimes feel a bit embarrassed to play guitar. There's something - I don't want to sound ungrateful - but there's something very old-fashioned and traditional about it. You meet kids today whose grandparents were in punk bands. It's very old and traditional, but then, so is an orchestra and so is a string section.

Vertical search engines that match your business, service or products with a target market offer you a higher conversion rate than traditional search engines. Because they have already qualified their interest by coming to a search engine with a specific focus, searchers will be more receptive to targeted advertising.

This rise of the new global mega-rich is happening as established institutions are falling. The fall runs the gamut from the music business and traditional media to the Detroit automakers who find themselves obsolete, outmaneuvered, and out-priced by entrepreneurs in Silicon Valley, Mumbai, Shanghai, and even Siberia.

I have been writing fairy tales for as long as I can remember. Not much has changed in terms of my natural attraction to the narrative techniques of fairy tales. My appreciation of them in the traditional stories has deepened, especially of flat and unadorned language, intuitive logic, abstraction, and everyday magic.

When we talk about dystopias, especially in young adult fiction, a lot of them are essentially science fictional futures. They aren't necessarily tied to the traditional concept of dystopia. And so in that space, my impression is that kids love reading about weird, wild, adventurous places, and dystopia fits that bill.

The nature of most Covid-19 deaths, in hospital or a care home away from family and friends, has made it worse for the people they leave behind. In the absence of the traditional rites and rituals of funeral and mourning - the opportunity to just share a hug - the process of bereavement has been made even harder to bear.

For Mitt Romney, the complex question of anti-Mormon bias boils down to the practical matter of how he can make it go away. Facing a traditional American anti-Catholicism, John F. Kennedy gave a speech during the 1960 presidential campaign declaring his private religion irrelevant to his qualifications for public office.

Kids don't need to be taught the value of making; they are natural makers, at least until traditional education makes them afraid of making mistakes. The long-term value of making for kids is in learning to become an active participant in the world around them rather than a consumer of prepackaged products and solutions.

I consistently run into young adults who have quickly turned away from traditional jobs at great companies to try their hand at a start-up. I believe that some of this stems from the desire to strike it big like Mark Zuckerberg, but I also believe it is because starting a company has become far cooler than working in one.

I'm a romantic, but I'm not a romantic in the traditional sense. I like to romanticize what happens to me. Whatever happens to me - you could quantify it as good or bad - I romanticize it. I think along the lines of 'When that thing happened, it made me who I am.' That kind of thing. It's a different way of being romantic.

I never finished the 'Large Glass' because, after working on it for eight years, I probably got interested in something else; also, I was tired. It may be that, subconsciously, I never intended to finish it because the word 'finish' implies an acceptance of traditional methods and all the paraphernalia that accompany them.

People always say, 'There are plenty of black country artists out there! There is Charley Pride! Darius Rucker!' That's all they can name. They don't understand what we go through, and a lot of people who are fans of traditional country music, as they call it, look at us and aren't going to say, 'Y'all like country music.'

Traditional Chinese art looked at the Earth from a Confucian mountain top; Japanese art looked closely around screens; Italian Renaissance art surveyed conquered nature through the window or door-frame of a palace. For the Cro-Magnons, space is a metaphysical arena of continually intermittent appearances and disappearances.

At the parish level, where the church lives and moves and breathes, that's where we need to be engaging our people much more in understanding the Word of God... the Word of God reflected in the traditional teaching of the church, the Word of God reflected in the scriptures, is as much a part of their lives as anything else.

Evolution explains our biological evolution, but human beings are very unique creatures. As the Dobzhansky said, all animals are unique; humans are the uniquest. And that uniqueness of being human, language, art, culture, our dependency on culture for survival, comes from the combination of traditional biological evolution.

Marriage is the most obvious public practice about which information is readily available. When combined with the traditional Jewish concern for continuity and self-preservation - itself only intensified by the memory of the Holocaust - marriage becomes the sine qua non of social membership in the modern Orthodox community.

We had put our son into a little preschool in Los Angeles, and it was just not going well, so we brought him back home. We had every intention of putting him back into a traditional school setting, but we just really couldn't find the right match for him. And then we moved to Georgia and again couldn't find the right match.

I think Donald Trump's interpretation of marriage is something that he himself doesn't really believe in. 'Traditional marriage' is where two people love each other, commit to each other, care for each other over the years. It is a meaningful ceremony, and his interpretation of that is not recognizing what real marriage is.

The traditional writer is a sensitive only child, asthmatic, who sits on the window seat watching the drops of rain slide down the pane, very introspective. I'm not inward-looking. I would never go to a shrink. I don't want to know what I'm thinking. I don't really like discussions in my family. It may be an avoidance thing.

What I love about what I get to do is that I'm allowed to create the stories that I want to tell with minimal interference by some very big corporations like Microsoft and Sprint and EA and BioWare. The advantage that these tech companies have is that they understand the space organically, versus traditional media companies.

It is true that traditional Christianity is losing some of its appeal among Americans, but that is a religious, not political, matter. It is worth remembering that the Jeffersonian 'wall of separation' between church and state has always been intended to protect the church from the state as much as the state from the church.

I always wrote. I wrote from when I was 12. That was therapeutic for me in those days. I wrote things to get them out of feeling them, and onto paper. So writing in a way saved me, kept me company. I did the traditional thing with falling in love with words, reading books and underlining lines I liked and words I didn't know.

The traditional family table is round. No corners. No sides. No head. No tail. Everything is smooth. The food is in the center, and each family member reaches over the same distance. Someone you love is next to you on each side, and no one is last or at the end. The person farthest away from you is also the person facing you.

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