We shot every scene of mine in the entire movie in five days. All my coverage, everything. I left. They went back and shot everybody else around me. Insane. The part [Billie in Crazy Six] called for a handsome, coiffed cool guy romantic lead, and I showed up like you see him in the movie. And they let me do it.

One of the interesting things about Twitter is looking how famous people choose to use it. Take someone like Steve Martin, who I follow: it's all sorts of comic gems, nothing private, nothing personal - all jokes. Other celebrities are overtly personal - like Charlie Sheen. I do a mix of observations and updates.

All the shows we did pre-airdate, and I'd come out - "Rob Lowe!" - and it was [Offers bored applause.] After the show aired? I came out - "Rob Lowe!" - and the place was, like, bedlam. And then the next week, they wouldn't let anyone under the age of 20 into the audience. And I'm going, "So that's how it works! Okay!"

I meet so many people. I want to be genuine and open with everyone, because when I was young and just starting out, I remember I was around people who were successful, and I thought that some were kind of cool or off-putting to their fans. It always really bothered me. So I think I may sometimes go too far out of my way.

In acting, there's a type of courage you're recognized for all the time. You lose 100 pounds and play a guy with AIDS, and you get rewarded. But, in life, doing what is courageous is quiet, and no one knows about it. Courage is someone making sacrifices for their family or making selfless decisions for what they hope or feel.

I love anything by Joan Didion. Incidentally, she was one of the local moms when I was growing up in Point Dume. She always reminded me a little bit of my mother, so I feel a great affinity. I love the precision of Didion's writing. There's a construction and a craftsmanship to her sentences that's imbued with so much emotion.

You can meet people who are really beautiful. Then, when you see them angry for the first time, all of a sudden they're not beautiful anymore. They didn't just step into the other room and have plastic surgery; they're still the same physically. It's just that something inside of them has changed. They're no longer attractive.

[Bad Influence]was David Koepp's first big screenplay. It was actually a writing sample that was around town to get David work at the time, and Steve Tisch - now the owner of the New York Giants - found it, loved it, and together we put it together. But I'd say that would be the one I'd tell people to go and look at if they haven't seen it.

I kind of pride myself on coming onto things that are well-oiled machines and finding a way to bring what I bring and fit in, and raise it to another level if I can. And this [Code Black ] has been another one of those really fun success stories, much like Parks And Recreation, although obviously on the other side of the comedy/drama equation.

[Doctor Cukrowicz] was basically a role where you have two diva actresses - Maggie Smith and Natasha Richardson - and my role was to say, "And then what happened? Tell me more." But I wanted to do it was because a) it was Tennessee Williams, a great writer, and b) it was Richard Eyre, an amazing director. And to work with those two amazing women!

I was... 15? And Garry Marshall, who had many, many seasons in the sun and a very long career, was in the middle of the brightest of all his seasons - I think he owned network television - and it was his next thing, and he was directing [Mean Jeans ]. And I thought, "If there's anyone who can bring comedy out of a designer jeans shop, it's gotta be Garry."

I'd done light comedy. In some quarters, About Last Night... is a romantic comedy. So it wasn't like I'd been doing Sophie's Choice my entire career. But for whatever reason, nobody had really given me the room or the ability to be out and out funny. And Lorne [Michaels] and Mike [Myers] and Chris [Farley] and Dana [Carvey], that crop really helped me do that.

Nothing in life is unfair. It's just life. To the extent that I had any inner turmoil, I had only myself to blame. I also thought of my two boys and what kind of example I hoped to be. I would always want them to take charge of their own futures and not be paralyzed by the comfort and certainty of the status quo or be cowed by the judgment of those on the outside looking in.

['John F. Kennedy] movie is based on a massive best-selling book, which is always helpful. And then the script was amazing and answered my question, "Why this? Why now?" And the "why now" is that it's 50 years since the assassination, and the country needs to have and will have a conversation about that. And the "why this" is the construct, which I think is sort of ingenious.

For the only time in my career, I came in and met Tony [Richardson] for the part - I did not read, I just met with him - and in the middle of the meeting, he told me that I had the part [in The Hotel New Hampshire]. There was never, "Well, thank you, and we'll have my people call your people." There was none of that kabuki that goes on now endlessly for even the smallest role.

I also listened to hours and hours and hours and hours and hours of [J.F.] Kennedy, and I sort of built [ accent]. And then I got on set [of 'J.F.Kennedy' movie ] and forgot it.But that's what you want to do. You want it to just be real. And I think authenticity was better than - people always talk about when an accent doesn't work, and the phrase you always hear is, "It was inconsistent."

We [me,Maggie Smith and Natasha Richardson ] rehearsed [Suddenly, Last Summer] like a play for a month, and then we shot it over the course of... I believe it was 10 days. All live, basically. Long, uninterrupted takes. And for me, a lot of it is me going head to head with Maggie Smith. And anybody who's ever had that opportunity never forgets it! It's a real career highlight, and it was everything I ever thought it would be, and more.

What kind of person would run for president of the United States in today's political climate? It would have to be somebody who's never really been drunk in public, who's never had an affair, who never shoplifted when they were a little boy, who never had any sort of counseling at all. I just don't know how you go through your life meeting people, experiencing everything you can, trying to absorb, and not make some of those mistakes. It's impossible.

We all have a suspicion and hope that we've just been part of something special, something that may eventually change our lives. That no one else knows this makes it seem like we are living with a secret that we would like to share, but can't, sort of like having a superpower that's not come online or being president elect. For the moment, our lives proceed as usual, but within a month, we think, everything will change. It's a frustrating, if exciting, disconnect.

Adventure is important in life. Making memories matters. It doesn’t have to be a secret sea plane and an historic sports moment. But to have a great life, you need great memories. Grab any intriguing offer. Say yes to a challenge, and to the unknown. Be creative in adding drama and scope to your own life. Work at it, like a job. Money from effort comes and goes. But effort from imagination and following adventure creates stories that you keep forever. And anyone can do it.

I’ve never agreed with the conventional wisdom that ‘actors are great liars.’ If more people understood the acting process, the goals of good actors, the conventional wisdom would be ‘actors are terrible liars,’ because only bad actors lie on the job. The good ones hate fakery and avoid manufactured emotion at all costs. Any script is enough of a lie anyway. (What experience does any actor have with flying a spacecraft? Killing someone?) What’s called for, what actors are hired for, is to bring reality to the arbitrary.

I think it was Alfred Hitchcock who said 90 percent of successful moviemaking is in the casting. The same is true in life. Who you are exposed to, who you choose to surround yourself with, is a unique variable in all of our experiences and it is hugely important in making us who we are. Seek out interesting characters, tough adversaries and strong mentors and your life can be rich, textured, highly entertaining and successful, like a Best Picture winner. Surround yourself with dullards, people of vanilla safety and unextraordinary ease, and you may find your life going straight to DVD.

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