Alzheimer's is a devastating disease. It was painful for me and my family to watch my grandfather deteriorate. We must find a cure for this horrible disease.

I think we all feel lucky, or at least I feel lucky, to get to be in their [Seth Rogen and Evan Goldberg] movies, and I'm not going to lie, I've nudged them.

Very often when I go in to meet for movies or pilots, I'm put on videotape. I hate the notion that that tape is going to sit on a shelf and never get better.

You can't afford for there to be gaps in your pool of knowledge when it comes to a character; otherwise, what ends up onscreen is generalized and unspecific.

Look in every city or any town. Travel by foot, or train or plane. Do not settle until there is love. For there, there will be the address of your happiness.

It's just a campy blast. I just want to do as little as I can and make it good, and try not to sell out. I'm sure I will, but I'm just trying to postpone it.

You can't manufacture a career as an actor because you aren't in control of what projects come to you, unless you are No. 1, two, three or four in the world.

Before I was an actor I was an apprentice jockey, and now I'm out there racing against boys, sort of the spokesperson for people over 50 that they can do it.

For all the import and message of 'The Iliad,' it's ultimately a story that's meant to be heard, and the person hearing 'The Iliad' determines what it means.

When I was a kid going to the movies, we'd go because Bogart was in the movie, or Cagney, or John Wayne. We didn't know what the story was about or anything.

This is my first experience working in a foreign movie, but the mechanics, I think, are pretty much the same all over; you still have to wait in the trailer.

A lot of people that I started out with, I don't know where they are. I guess it takes tenacity to still be doing this, and luck, but I've been very blessed.

A man once told me that you step out of your door in the morning, and you are already in trouble. The only question is are you on top of that trouble or not?

I have a new respect for filmmakers, that's for sure, 'cause it's not easy. If I'm allowed to, I'll be directing for the rest of my life. I love the process.

The American people hit the streets and did something that the government wouldn't do: the Civil Rights Act. It didn't go down well with the corporate world.

Harrison Ford was pretty content as a carpenter who thought it would be nice to work on TV and ended up being the biggest film star in the history of cinema.

I'd been very certain about not wanting to do the acting thing because of my father. I thought I'd always have the father-son thing of 'He got you the part.'

The first lead that I ever played was a young Boy George when I was seventeen. I shaved my eyebrows off. That's as far from leading man looks as you can get.

I don't think there's hardly a comic out there that does clean material all the way around. There's a couple of guys that are clean, but I'm not one of them.

I looked at game show hosting as the bottom of the totem pole, one step away from infomercials. I never watched them myself. However, it's been a lot of fun.

When you try hard at everything you do, even when it feels foolish to do so, you’re opening up doors and possibilities you might not be seeing in the moment.

You see a lot of sides of people on a movie set because it can be really taxing and to kind of go through all that together - you really get to know someone.

We all have very personal relationships to what happened on 9/11 and the events after tracking Osama bin Laden. Nobody can escape from the influence of that.

I always felt that acting was an escape, like having the secret key to every door and permission to go into any realm and soak it up. I enjoy that free pass.

As a television actor, there's a power you're given to use your image to do something valuable. As a parent, these messages are particularly important to me.

I hope that dog lovers around the world will support the Cruelty Free International global campaign to end the use of dogs in outdated and cruel experiments.

I believe in the healing restorative power of art and communication. And so that's probably my rule. But that doesn't apply to bedtimes. And stuff like that.

I'm not the best actor I can be, so I'm just working on it. I'm not the quickest reader in the world but when I get an acting book I can read it in two days.

I'm doing my bit for the women's movement. The women have always been naked in movies, and now I'm just desperate to take my clothes off as much as possible.

Getting socially outcast can be the best and most informative thing that can ever happen to you because you have to learn who you are separate from the pack.

When children and youth are deprived of their right to education, their community is deprived of a sustainable future. It is all the more true with refugees.

I'm crazy about westerns. I need to do a western once in a while. It's like you know, eating bread, eating pasta, drinking wine. It's in my blood. I need it.

I try to maintain a high level of coolness. Which means I've gotta look at lot of magazines. I've gotta look at a lot of ads to see what people want to wear.

Looking back, I was a very good kid, very studious and all. But I would always come out with a quip - and I was sent to the principal's office several times.

And then, I suppose, there's also a cinematic reality on top of that. Because it was extremely difficult to keep tabs on, it was quite confusing acting that.

I'm not a very gregarious person. I can't bear attention being called to me in a public place, which is ridiculous in a business that pays you to be noticed.

I took a bit of a back seat, I had kids and I wanted to focus on them. There's that period in the late '90s, the early 2000s, where I didn't do a great deal.

Honesty isn't enough for me. That becomes very boring. If you can convince people what you're doing is real and it's also bigger than life - that's exciting.

Directors are the captains of the ship, and it's your job as the lead actor to make sure that the rest of the cast understand that by doing whatever he says.

In the United States 95% of the people who win elections have the most money. That's it. So, money is a big part of elections. But that happens all the time.

Authenticity is the ability to listen to what nature tells us. Listening isn't the same thing as never making a mistake, but the important thing is to learn.

I just want to serve up the goodness and grace that's been given to me because I made a choice that lined up with my passion. And that's what I tell my kids.

What an actor says is much, much less important than a life, so that's the great use for improvisation; you go, you find the life and then you add the words.

My job is to come up with something that you like and you agree with that you would play wholeheartedly. If we disagree, I may not be doing my job correctly.

Everyone's life would be improved if they do could one great magic trick. And tell one great joke, play one tune on the piano, and do one great origami fold.

I'm training two-and-a-half hours a day, pushing my body beyond its normal limits, putting on a lot of muscle mass and just making myself look like Superman.

Especially for this film [ 47 ronin] there's a nice mixture between western and eastern. So Ronin wearing the boots, like Western style. It's a nice mixture.

If you're going to play a champion athlete, people expect you to look a certain way, and you also have to have the stamina to be able to continue to perform.

In real life, I try to be honest but not overshare. There are people that turn every conversation into a therapy session and you want to start charging them.

I think that women don't bother disguising their desire and pleasure in dressing up, and that men, for whatever reason, tend to be a little more embarrassed.

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