I have played bad-guy roles, but they were significant to the story.

Most presidents have not considered 100 days a significant milepost.

My significance is found in pointing to Someone far more significant.

If we want any significant development, we must co-opt civil society.

[On cooking:] What you keep out is as significant as what you put in.

It's a significant contribution if we can get immigration reform done.

Men are hugely significant to me and to many of the women I interview.

The more involved you are, the more significant your learning will be.

All interested parties must be willing to make significant sacrifices.

Art is the ability to separate the significant from the insignificant.

There is a difference between who is important and who is significant.

My last meal? The food would be much less significant than the company.

There is a significant Latin proverb; to wit: Who will guard the guards?

The hidden Trump vote in this country is a very significant proposition.

Physics is the most fundamental, and least significant, of the sciences.

The most significant social pathology of my youth was the generation gap.

We are not a minor power in the Middle East; we are a significant player.

Youth - the most significant aspect of youth is that it's full of energy.

Anybody who has traveled with a significant other before knows it's tough.

Don't turn on monitization, typically, until it's going to be significant.

What happens in New York affects national policy in very significant ways.

Even a small reduction in errors and rework can have a significant impact.

I never really dyed my hair anything significant from my natural hair color.

At HSN, the experience we create are a significant point of differentiation.

To give someone a blessing is the most significant affirmation we can offer.

I believe that the Holocaust is the most significant event in human history.

The best time to do something significant is between yesterday and tomorrow.

I will work in films based on quality productions and significant characters.

Anyone who spends a significant amount of time with me finds me disagreeable.

I lived a significant portion of my life before the Internet and smart phones.

I've always been motivated to innovate where the implications are significant.

There's no chance that the iPhone is going to get any significant market share.

Only black holes of very low mass would emit a significant amount of radiation.

It is a familiar and significant saying that a problem well put is half-solved.

What makes things memorable is that they are meaningful, significant, colorful.

Latino poets, are really having a significant impact on American poetics today.

Letters are among the most significant memorial a person can leave behind them.

I feel that I have something significant to say, but I cannot think what it is.

Terrorism is a significant threat to peace and security, prosperity and people.

Just feeling free to walk out on stage and be myself is pretty damn significant.

It is better to live on the house top than to live in a house full of confusion.

The legal difference between the sit-ins and the Freedom Riders was significant.

The military is arguably the most significant social institution in our country.

Many significant stock-price inefficiencies can occur when a company is spun off.

The significant collapse of oil prices shows that it was previously way too high.

Our most significant opportunities will be found in times of greatest difficulty.

Literature is one of the most interesting and significant expressions of humanity.

Entering 2015, the coal industry clearly continues to face significant challenges.

What transpires for the least significant member transpires at once for the whole.

I'm only 5ft 2in so a significant increase in weight is really going to be noticed.

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