Brexit is not ideal. I'm famously not a Brexit negotiator, but relations between Ireland and the U.K. have been getting stronger, and a big part of that has been trade and feeling like sister countries within the E.U. I don't think it will affect the 'vibe' of relations, but it will have a significant effect on trade and business.

If you go all the way back, I've always written science-fiction, I've always written fantasy, I've always written horror stories and monster stories, right from the beginning of my career. I've always moved back and forth between the genres. I don't really recognise that there's a significant difference between them in some senses.

At a time when many churches throughout the world are experiencing significant decreases in numbers, The Church of Jesus Christ of Latter-day Saints - though small in comparison with many others - is one of the fastest growing churches in the world. As of September 2013, the Church has more than 15 million members around the world.

There is a natural tendency for investors to devote a significant majority of their time to finding new ideas. After all, uncovering great companies selling at great prices is the lifeblood of successful investing. But in the never-ending quest for the next great idea, investors often give short shrift to their existing investments.

If it's possible, 2018 was a year in which it felt like everything was changing, and also like nothing was. While we set our global expectations for the next one, teeming with significant political, social and economic volatility, we're also considering more local possibilities - changes within our own communities, homes and bodies.

You can go online now and find really thoughtful, in-depth, considered, well-informed communities around virtually any issue. If it's your issue, there are now new ways of mobilising knowledge that weren't there before. There are real bodies of significant knowledge on the web that are valuable that we haven't done nearly enough with.

Many Western nations have made significant gains through automation and operational excellence, while emerging markets rely on ever-increasing numbers of workers. Each will improve their competitive position only by examining every element of operations to make existing resources more efficient and to deliver real value at lower cost.

Open access is good, but we have to have ways and means where content that has been generated with a lot of effort and cost also gets the chance to monetise itself as is now beginning to happen in the West where some publications are really beginning to make their Internet revenue lines and subscription revenue lines quite significant.

After a two-term presidency, many young voters seem to want someone who is radically different from, even the opposite of, the commander in chief to whom they have become accustomed. After all, a two-term president will have led their nation for a significant percentage of their lives. That's boring. Isn't it time for a transformation?

I knew I wanted the parties in 'The Queen of the Night' to be convincing, beautiful, and also dramatic: situations where significant things happened on a scale that was both grand and intimate. There were several texts that helped me think about how to do this, and one of the most important ones was Charlotte Bronte's novel 'Villette.'

My point is cutting spending shouldn't be reliant on the debt limit though. It's something we have to do. The good news for America is, leaders in both parties, the president, believe that we have to have significant deficit reduction. So the intent is there. And I think what America is going to demand is that our leaders come together.

Readers tell me that my novels are filled with significant mothers. Do I realize this? Do I do it on purpose? The truth is, I don't. I think of myself as a writer of family stories. I write more often than not from a male point of view, and I usually begin by focusing on siblings, spouses, even fathers, before I think about the mothers.

Policing has to be done compassionately and consistently. You cannot police differently in Harlem than you're policing downtown. The same laws must apply. The same procedures must be employed. Certain areas at certain times may have more significant crime and require more police presence or more assertiveness, but it has to be balanced.

Since the global financial crisis and recession of 2007-2009, criticism of the economics profession has intensified. The failure of all but a few professional economists to forecast the episode - the aftereffects of which still linger - has led many to question whether the economics profession contributes anything significant to society.

My goal is to reach out to communicate every day, whether I'm in Washington or in the congressional district. In Washington, the best opportunity to do that is on the House floor. It's both a responsibility and an opportunity. I enjoy, every day, taking to the House floor to address an issue or event that is significant for constituents.

The Strauss Group identified water as a strategic category presenting significant business opportunity in line with the Group's long term business strategy and vision. We view the development of a technology that enables high quality drinking water for both home and offices as a means to improve the quality of life of millions of people.

My parents were working class folks. My dad was a bartender for most of his life, my mom was a maid and a cashier and a stock clerk at WalMart. We were not people of financial means in terms of significant financial means. I always told them, 'I didn't always have what I wanted. I always had what I needed.' My parents always provided that.

We no longer have a significant middle class in the US due to Barack Obama's job-killing ban on oil drilling in Zion Park. While a small middle class remains in the coastal blue states, our tax bill devastates them by curbing deductions for state and local taxes and large mortgages. In a few years, everyone except the 1% will be a tricklee.

I forget what the relevant American rate is, but I can tell you that our goal is to have a combined federal-provincial corporate tax rate of no more than 25 percent. We're on target to do that by 2012. We will have significantly - by a significant margin the lowest corporate tax rates in the G-7, and that's our - our government's objective.

After two years working with bitcoin and blockchain companies and corporate leaders, we identified that a significant issue hindering the widespread, global adoption of blockchain is the inability to quickly connect with the right combination of partners for testing and deployment of the technology to address real-world business challenges.

I think part of the thing that is important to me, and is important to Labour supporters, is that the fight goes on. The fight goes on in relation to this budget, in relation to Europe, and in a way, the history of progressive politics is that there are setbacks - significant setbacks - and you have to overcome that. But obviously it's tough.

The specter of climate change threatens worsening natural disasters, rapid urbanization, forced migration, and economic hardship for the most vulnerable. Despite significant global advances, inability to effectively address epidemics and health emergencies still prevail and continuously threaten global health security and economic development.

I'm from a working-class family. We didn't have a lot, but we had the arts. You're talking to a guy who is making a living at doing what he loves doing - acting, singing and dancing. So any career ups and downs were not that significant to me; the only things that really powerfully impinged on me were my losses, and there were many in my life.

We believe that such a significant increase in longevity is due to the protective effect against cancer produced by caloric restriction - incidences fall by 40 percent if we compare them with the mice that produce more telomerase and have a normal diet - and, added to the presence of longer telomeres, this makes the mice live longer and better.

When we look at government in Washington or what's happening on Wall Street, we see so much centralization. But really, our goals should be to eliminate and overcome these central institutions. And in recent years we have gained powerful new tools to do this, and most significant among those is the block chain, which is the software behind Bitcoin.

I am very hopeful that my personal success in Qatar will ignite others, especially those in the so-called non-traditional sports, to try even harder because now they can see for themselves that significant achievements can be attained. But let me stress that it takes a lot of work - in fact, very hard work - mixed with very heavy doses of patience.

What people don't understand is that the underground that existed was created in the early 80s and was thriving throughout the 80s. Until the industry showed up it was a pretty significant network. It was all happening, but the smell of money had not wafted up high enough for the industry. It wasn't really until they came descending on Seattle that things really got out of control.

The pendulum of cookery techniques became more significant than the actual experience. And when that happens, the customer's satisfaction becomes secondary to the chef's satisfaction. And in that case, you have an upside-down equation. Because the customer is the basis of our restaurant, first of all, and if the chef becomes the most important person at the table - even more so than the guests - then suddenly you're left with something that doesn't really work.

There's one last thing we need to point out. And it is a fact that Puerto Rico is a colonial territory of the United States. This puts us in a very significant disadvantage to all of the other states and to all of the other American citizens. As a matter of comparative, the U.S. citizens, the Puerto Ricans that live in the United States have much better incomes, more than twice as much, participate in the labor force of greater scales, have better results in the education system and so forth.

Let's take something like antidepressant medications. There's decent science saying it has an effect, but it's shockingly small after you control for penetration of the blind, people knowing that they're getting the active pills versus sugar pills, if you use an active control. It's probably only a few points. But it's a multi, multibillion-dollar industry. And by the way, has huge side effects. 40 percent of the people taking them have significant sexual side effects. And that's just one. A single antidepressant medication can be worth a billion dollars to a company.

The papers that flourish will be papers that serve a national audience. Papers that have figured out how to make the transition to the electronic platform that aren't simply providing a duplicate experience of the words on paper experience, but are doing something that arises organically from the new electronic medium. It's really just a matter of finding the right platforms for the way people want to read newspapers. I mean, maybe it will be the iPhone. But one way or another, newspapers on paper are just not really going to exist to any significant degree within a decade.

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